By Dhia Aldoori November 22, 2021
I have updated my knowledge and stance on ivermectin use in humans for treating the SARS-CoV-2 viral infection to where I consider it to have potential benefit in treating severe cases of COVID 19. I may endorse (not yet though) its regular use in severe cases after randomized controlled trials are carried out on it.[1]–[6][7],[8]
Bibliography:
[1] S. Ahmed et al., “A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness,” Int. J. Infect. Dis., vol. 103, no. 0, pp. 214–216, Feb. 2021, doi: 10.1016/j.ijid.2020.11.191.
[2] N. Okumuş et al., “Evaluation of the effectiveness and safety of adding ivermectin to treatment in severe COVID-19 patients,” BMC Infect. Dis., vol. 21, no. 1, 2021, doi: 10.1186/s12879-021-06104-9.
[3] S. Lehrer and P. H. Rheinstein, “Ivermectin docks to the SARS-CoV-2 spike receptor-binding domain attached to ACE2,” In Vivo (Brooklyn)., vol. 34, no. 5, 2020, doi: 10.21873/invivo.12134.
[4] J. C. Rajter, M. S. Sherman, N. Fatteh, F. Vogel, J. Sacks, and J.-J. Rajter, “Use of Ivermectin Is Associated With Lower Mortality in Hospitalized Patients With Coronavirus Disease 2019,” Chest, vol. 159, no. 1, pp. 85–92, Jan. 2021, doi: 10.1016/j.chest.2020.10.009.
[5] F. Heidary and R. Gharebaghi, “Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen,” Journal of Antibiotics, vol. 73, no. 9. 2020, doi: 10.1038/s41429-020-0336-z.
[6] L. Caly, J. D. Druce, M. G. Catton, D. A. Jans, and K. M. Wagstaff, “The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro,” Antiviral Res., vol. 178, 2020, doi: 10.1016/j.antiviral.2020.104787.
[7] G. Momekov and D. Momekova, “Ivermectin as a potential COVID-19 treatment from the pharmacokinetic point of view: antiviral levels are not likely attainable with known dosing regimens,” Biotechnol. Biotechnol. Equip., vol. 34, no. 1, pp. 469–474, Jan. 2020, doi: 10.1080/13102818.2020.1775118.
[8] “Ivermectin | COVID-19 Treatment Guidelines.” [Online]. Available: https://www.covid19treatmentguidelines.nih.gov/therapies/antiviral-therapy/ivermectin/. [Accessed: 22-Nov-2021].
